Publications

See our presentations on Dravet syndrome and ADOA.

Dravet Syndrome Presentations

Electrophysiological improvements in patients with Dravet syndrome following treatment with zorevunersen, an investigational antisense oligonucleotide

AAN 2026

April 20, 2026

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Zorevunersen demonstrates potential as a diseasemodifying therapy in patients with Dravet syndrome through durable seizure reduction and improvements in cognition, behavior, and quality of life through 36 months of treatment in open-label extension studies

AAN 2026

April 20, 2026

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Zorevunersen in Children and Adolescents with Dravet Syndrome

The New England Journal of Medicine

March 5, 2026

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Zorevunersen continues to demonstrate potential as a disease-modifying therapy in long-term open-label extension studies of patients with Dravet syndrome​

AES 2025

December 5, 2025

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Zorevunersen continues to demonstrate potential as a disease-modifying therapy in long-term open-label extension studies of patients with Dravet syndrome

AES 2025

December 5, 2025

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Zorevunersen demonstrates disease-modifying potential in patients with Dravet syndrome with increases in seizure-free days, improvements in quality of life, and benefits in overall clinical status

AES 2025

December 5, 2025

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Spectral electroencephalogram abnormalities across development in patients with Dravet syndrome

AES 2025

December 5, 2025

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Electrophysiological improvements in patients with Dravet syndrome following treatment with zorevunersen, an investigational antisense oligonucleotide

AES 2025

December 5, 2025

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Zorevunersen demonstrates disease-modifying potential in patients with Dravet syndrome through durable seizure reduction and continuing improvements in cognition, behavior, and functioning through 36 months of treatment in open-label extension studies

CNS 2025

October 9, 2025

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Substantial improvements in overall seizure burden and seizure-free days in patients with Dravet syndrome treated with zorevunersen: Results from Phase 1/2a and open‑label extension studies

IEC 2025

September 1, 2025

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EMPEROR Phase 3 study design: Evaluation of zorevunersen as a potential disease-modifying therapy for Dravet syndrome

IEC 2025

September 1, 2025

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Zorevunersen demonstrates potential as a disease-modifying therapy in patients with Dravet syndrome through durable seizure reduction and improvements in cognition, behavior, and functioning with up to 36 months of maintenance dosing in open-label extension studies

IEC 2025

August 31, 2025

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Zorevunersen demonstrates potential as a disease-modifying therapy in patients with Dravet syndrome through durable seizure reduction and improvements in cognition, behavior, and functioning with up to 24 months of maintenance dosing in open-label extension studies

EPNS 2025

July 10, 2025

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Zorevunersen (STK-001) demonstrates potential for disease modification, including reductions in seizures and improvements in cognition and behavior in children and adolescents with Dravet syndrome

AES 2024

December 6, 2024

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Patients with Dravet syndrome in open-label extension studies of zorevunersen (STK-001) have durable reductions in seizure frequency and ongoing improvements in cognition and behavior

AES 2024

December 6, 2024

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Small changes on the Vineland-3 are meaningful to caregivers of patients with Dravet syndrome

AES 2024

December 6, 2024

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Spectral EEG analysis demonstrates decreased slow-wave activity in patients with Dravet syndrome after treatment with zorevunersen (STK-001), an antisense oligonucleotide

AES 2024

December 6, 2024

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24-Month Analysis of BUTTERFLY A Prospective, Observational Study to Investigate Seizures and Comorbidities in Children and Adolescents with Dravet Syndrome

EEC 2024

September 10, 2024

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Featured Publications

Zorevunersen in Children and Adolescents with Dravet Syndrome

The New England Journal of Medicine

March 5, 2026

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Toward a Disease-Modifying Therapy for Dravet Syndrome

The New England Journal of Medicine

March 5, 2026

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Natural History of Children and Adolescents With Dravet Syndrome: A 24-Month Follow-Up

Neurology

November 14, 2025

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Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

Science Translational Medicine

August 26, 2020

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Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Nature Communications

July 9, 2020

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