Boldly Restoring Genetic Health
Restoring protein expression by harnessing the body’s potential with RNA medicine.
TANGO: Restoring Missing Proteins
Targeted Augmentation of Nuclear Gene Output, or TANGO, is our proprietary research platform. Unlike other RNA-based approaches, TANGO aims to restore missing proteins by increasing – or stoking – protein output from healthy genes, thus compensating for the non-functioning copy of the gene. Stoke’s initial applications for this technology are diseases in which one copy of a gene functions normally and the other is mutated, also called haploinsufficiencies. However, our research has shown that TANGO can increase full-length, fully functional protein expression from a variety of healthy genes. These findings support our belief that our approach may lead to an entirely new way of treating many severe diseases.
Dravet Syndrome
Dravet syndrome is a severe and progressive genetic epilepsy characterized by frequent, prolonged and refractory seizures beginning within the first year of life. The effects of the disease go beyond seizures, including intellectual disability and developmental delays. Our goal is to develop the first disease-modifying therapy to address the genetic cause of Dravet syndrome.
The Future of our Science
We are fearless in our pursuit to realize the full potential of TANGO to help people who are living with severe diseases. Clinical studies of zorevunersen (STK-001) for the treatment of Dravet syndrome are ongoing. We have demonstrated promise for a TANGO ASO to treat the underlying cause of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. We continue to explore the potential for TANGO in a number of other diseases.
Using Science to Change People’s Lives
Stoke was founded on the idea that we could use unique insights in RNA biology to do something that has never been done before: increase protein output from healthy genes using an RNA-based approach. Our team is making progress on turning that vision into reality.
Spark Your Career
We are fired up about science and our ability to make a difference for people living with severe diseases. We are purposefully inclusive, bring our authentic selves to work each day and, despite our serious mission, look to have fun while we’re at it. We invite you to learn more about what we’re doing and how you can make a difference.
