Senior Research Associate, Discovery Biology

Stoke is seeking to hire a Senior Research Associate with a strong background in cell and molecular biology research. The candidate will report to an Associate Principal Scientist in the Discovery Biology Group and support ongoing research efforts in developing oligonucleotide-based therapies. The candidate is expected to perform the following activities:

Key Responsibilities:

  • Work in aseptic conditions and maintain cultures of various cell types.
  • Screen and evaluate oligonucleotide-based drug candidates and plasmids in cell-based assays by nucleofection, transfection.
  • Perform cell and molecular biology techniques such as RNA and protein isolation, RT-PCR, RT-qPCR, in 96 and 384 well formats.
  • Perform protein assays- western blot, ELISA and MSD assays.
  • Troubleshoot experiments, analyze and interpret data, participate in development of new assays.
  • Maintain accurate documentation of experiments in electronic lab notebook (ELN).
  • Write technical reports and protocols, with guidance from supervisor.
  • Present research findings at group meetings and occasional company-wide and external meetings, as necessary.
  • Work independently as well as collaborate with peers in a result-oriented research environment.

Required Skills & Experience:

  • Senior Research Associate: B.S. with a minimum of 5+years post-graduate experience in molecular and cell biology research, or M.S. with a minimum of 2 years post-graduate experience in molecular and cell biology research
  • Strong hands-on experience in RNA isolation techniques RT-qPCR and protein assays.
  • Mammalian cell culture and cell-based assays is a must.
  • Experience with viral vectors is a plus but not required.
  • Strong organizational and recordkeeping skills.


Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.


This position will require 10-15% travel.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

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