Stoke is seeking a highly motivated Program Leader to join a company pioneering genetic disease treatments. This Director level position is responsible for providing expertise and leadership in a preclinical program for Autosomal Dominant Optic Atrophy (ADOA) and additional preclinical programs as appropriate. The program Leader will work closely with the Senior Program Manager, Chief Scientific Officer (CSO) and Chief Medical Officer (CMO) to develop and manage the integrated development plan. This position will report into the Chief Scientific Officer.
- The candidate will lead the cross-functional drug development team through preclinical phases to support Stoke Therapeutic’s ADOA program to ensure delivery of a high-quality efficacy and safety package for development.
- Provide direction and leadership to the ADOA program team including setting strategy, scientific oversight of activities, data review based on key milestones, budget, and planning.
- Proactively identifies challenges, risks, and prepares team with mitigations to navigate team through technical and program challenges as they arise.
- Work closely with the Senior Program Manager to determine program goals, priorities, resource requirements, budget, and timelines.
- Collaborate with discovery, DMPK, Toxicology, Chemistry/CMC functions as well as with key Clinical and Regulatory stakeholders.
- Responsible for the preparation and presentation of project team data to senior management and BOD to drive decision making and to support regulatory filings.
- Represent Stoke Therapeutics with key external stakeholders and partners as needed.
Required Skills & Experience:
- Advanced scientific degree (MD, or PhD, or PharmD). in a relevant discipline with at least ten years of post-graduate and drug development experience.
- Strong experience with drug development in the eye and/or CNS is required.
- 5+ years of experience leading cross-functional development teams, especially in late preclinical (pre-IND) through early clinical development
- Some experience with oligonucleotides or messenger RNA is preferred.
- Familiarity with GLP regulations and ICH/FDA guidelines is a plus.
- Strong organizational and recordkeeping skills.
- Strong presentational skills to be able to communicate to both internal and external audiences.
- Ability to work as a team player in a dynamic environment.
This position will require approximately 20% travel to necessary meetings.
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events, and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.
Benefits & Compensation:
At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.