Join Our Team
At Stoke, we are building a team of talented scientists, experienced drug developers and insightful leaders to address severe genetic diseases.
We are excited about breaking new scientific ground. This work is challenging, but we know we have the team to do it. We’re united around a common goal: to improve the lives of people living with severe genetic diseases.
Current openings
Stoke is always looking for individuals with a passion for developing precision medicines to tackle severe genetic diseases.
Scientist, Discovery Biology
Stoke is seeking an enthusiastic, motivated Scientist. The candidate will be responsible for advancing our Platform capabilities and taking novel drug products into preclinical Proof-of-concept studies.
Key Responsibilities:
- Independently design and execute molecular assays to identify preclinical drug candidates targeting disease genes.
- Develop high-quality assays to inform disease target gene engagement in cell and animal models.
- Collaborate with internal groups to identify new Stoke disease targets.
- Work with CRO laboratories and external collaborators to support internal studies.
- Maintain accurate documentation of experiments in ELN.
- Author reports and contribute to manuscripts and patent filings.
- Present results at cross-functional team and lab meetings.
Required Skills & Experience:
- Ph.D. in molecular biology / related field, or, MS with 8 years or more of relevant experience working in the industry.
- Proven hands-on experience in vector cloning, cell culture, molecular biology, gene expression analysis and assay development.
- Ability to interpret and trouble shoot experiments independently.
- Excellent problem-solving skills and ability to work as a team player in a dynamic environment.
- Excellent communication and presentation skills required.
- Proficient in standard Microsoft Office tools: Word, Excel, and PowerPoint.
- Strong attention to detail and organizational skills.
- Prior gene therapy experience is a plus.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Apply Here
Associate Scientist, Discovery Biology
Stoke is seeking an enthusiastic and highly motivated Associate Scientist to join the Discovery Biology group. The successful candidate will have a strong interest and background in molecular biology research. The candidate will contribute to the early discovery efforts that Stoke undertakes to identify, evaluate and propose disease-associated gene targets that will populate the company’s pipeline. This will include evaluating antisense oligonucleotides for therapeutic potential beginning at the target validation stage, followed by hit identification, and finally generating a data package for target nomination. The candidate will be responsible for independently implementing and executing biochemical or cellular assays to support/advance the Discovery Biology group activities. The candidate will perform the following activities:
Key Responsibilities Include:
- Perform cell and molecular biology techniques including RNA isolation, protein isolation, RT-PCR, qPCR, western blot, and other project-specific assays, as necessary.
- Troubleshoot experiments, analyze and interpret data, and participate in development of new assays.
- Maintain accurate documentation of experiments in Electronic Lab Notebook and draft technical reports.
- Present research findings at group meeting, company-wide presentation, and external meetings.
- Be able to work independently as well as collaborate with peers in a results-oriented environment focused on generating life altering therapeutics.
Required Experience:
- Associate Scientist: MS with a minimum of 5 years post-graduate experience or bachelor’s with a minimum of 7 years post-graduate experience
- Experienced in mammalian cell culture techniques.
- Experience in molecular biology/RNA isolation techniques.
- Experience in RNA metabolism/splicing is a strong plus.
- Previous work with antisense oligonucleotides is a plus.
- Strong organizational and recordkeeping skills. Strong oral and written communication skills.
Travel:
Approximately 5% of this position will require travel.
Location(s):
This position will primarily be located in Bedford, Mass.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Apply Here
Associate Scientist, Biomarker Development
Stoke is seeking an enthusiastic, collaborative and technically excellent laboratory-based Scientist with a strong biomarker discovery background to join the Bioanalytical, DMPK and Biomarker Development group. The candidate will be responsible for biomarker discovery, assay development and implementation. The specific responsibilities include but are not limited to:
- Independently develop high-quality assays to quantitate biomarkers in biospecimens from preclinical and clinical studies, interpret results and report data to support biomarker discovery efforts.
- Evaluate a variety of platforms including immunoassays and implement “fit for purpose” assays as necessary.
- Participate in clinical biomarker sub team that includes representatives from research, pharmacology and DMPK functions.
- Characterize/evaluate critical reagents including protein reference materials, antibodies, and reagents to ensure quality and stability.
- Assist in outsourcing and manage relationships with CRO laboratories to transfer, qualify/validate bioanalytical assays, coordinate sample shipments and support assay implementation.
- Prepare protocols and standard operating procedures (SOPs).
- Present results at cross-functional team and lab meetings.
- Maintain accurate documentation of experiments in ELN.
- Help maintain the bioanalytical lab and keep the instruments running properly.
Essential Skills & Experience:
- B.S/M.S. with a minimum 7 years of relevant experience is required preferably in pharmaceutical or biotechnology company.
- Strong hands-on experience in developing, implementing and executing ligand binding assays (ELISA, MSD-ECL, Luminex, Singulex, Simoa etc.) to quantify analytes in biofluids or tissues is a must.
- Good understanding of bioanalytical and biomarker assay development, validation and implementation using a variety of platforms e.g. qPCR, Western blots, immunoassays.
- Excellent attention to detail, organizational, communication and problem-solving skills, and ability to work as a team player in a dynamic environment.
- Familiarity with regulatory expectations (FDA and EMA) and industry’s best practices in validation of biomarker assays is desired.
- Prior drug development experience in nucleic acids-based therapeutics and testing biological matrices for PK/PD evaluation is a plus.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.
Apply Here
Head of Investor Relations
The Head of Investor Relations will play a critical role in leading the company’s investor engagement strategy and delivery. Reporting to the Vice President, Head of Corporate Affairs, this individual will play a leadership role, interacting with Stoke’s executive team to guide and manage ongoing investor relations activities in support the company’s goal of ensuring an accurate understanding of the company’s vision, strategy and its fair valuation. Serving as second in command to the VP, this person will contribute to many aspects of Stoke’s corporate communications efforts, helping to build and lead the Corporate Affairs function as the company continues to evolve.
Key Responsibilities Include:
- Collaborate with the VP, Head of Corporate Affairs to develop and implement an investor relations strategy and plans.
- Lead the development and implementation of the company’s Investor Relations strategy and execution, including day-to-day management of investor interactions and events (corporate calendar, non-deal roadshows, conference management, briefing materials, corporate presentations, bus tours, etc.).
- Work closely with executive leadership to establish the optimal mix of shareholders for Stoke at each stage of its evolution through strategic and thoughtful targeting initiatives.
- Work closely with cross-functional leaders and colleagues to stay current on company progress to guide investor-focused communications and then work collaboratively on materials development such as press releases, backgrounders, fact sheets, website content, Q&As, presentations, call scripts, executive talking points, social media posts, internal communications and intranet content.
- Serve as a primary point of contact for all investor inquiries; cultivate and maintain strong relationships with investors (current and potential future), sell-side research analysts, media and other key stakeholders. Provide timely, consistent, compliant and accurate responses.
- Effectively anticipate investor concerns, questions and needs by keeping current on the industry and competitive landscape while maintaining a deep understanding of Stoke’s business and progress.
- Monitor and assess market and sector dynamics as well as all investment research (including models and estimates) on Stoke and its industry peers. Provide data and metrics-driven insights into the market and competitive landscape, using the information to counsel Stoke management and guide investor communications and activities.
- Continuously evaluate Stoke’s performance with investors and use data as well as keen observation and critical thinking skills to continuously improve Stoke’s ongoing investor engagement.
- Partner closely with Finance, Legal and other departments to ensure accurate and appropriate information for financial reporting, including as part of quarterly communications and regular SEC filings.
- Serve as an internal resource for communications counsel and assist with the departmental activities including helping maintain the website, social media channels, executive visibility and patient advocacy efforts.
- Manage external agencies and vendors that are supporting investor communications and activities.
Required Experience:
- Bachelor’s Degree, preferably in Journalism, Communications, Business, Finance, Accounting or a related field. Post-graduate degree a plus.
- 7+ years of experience in the biotech or pharmaceutical industry working for/on behalf of publicly-traded, high-growth companies. Experience in investor relations, corporate communications, corporate strategy, equity research, investment banking and/or finance.
- Excellent communications skills: written, verbal and presentation delivery.
- Demonstrated ability to simplify complex information and distill it into clear, concise and simple messages that help to effectively communicate the company story.
- Results-driver with proven ability to identify and analyze business dynamics to develop and implement plans to support investor relations activities.
- Strategic thinker and problem solver; intellectually curious and perceptive; able to identify interdependencies and connections across the business; a critical thinker.
- Comfortable in a fast-moving, rapidly changing environment; able to establish structure and process when needed; consistently prioritizes high-impact projects; calm under pressure; works with a sense of purpose and urgency.
- Appreciation for laws and regulations governing the industry and publicly-traded company communications and investor engagement activities.
- Holds self and others to a high standard of ethics and integrity. Maintains confidentiality, exercises good judgment and discretion.
- Demonstrated ability to lead, influence and collaborate across the organization and at all levels, both internally and externally.
- Able to work independently with minimal supervision.
Travel:
Once investor and other meetings and conferences return to being conducted in-person, it is anticipated that approximately 25-35% of this individual’s time will be spent traveling, primarily to New York and other areas with high investor concentrations as well as other medical conferences and industry meetings.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. The individual in this role will be an integral contributor to the team, working closely with their manager and members of the executive leadership team, and may be based primarily in one of the two locations with the ability to work from the other location as the need arises.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.