Join Our Team
At Stoke, we are building a team of talented scientists, experienced drug developers and insightful leaders to address severe genetic diseases.
We are excited about breaking new scientific ground. This work is challenging, but we know we have the team to do it. We’re united around a common goal: to improve the lives of people living with severe genetic diseases.
Current openings
Stoke is always looking for individuals with a passion for developing precision medicines to tackle severe genetic diseases.
Vice President, Human Resources
Stoke is seeking an enthusiastic and highly motivated Vice President of Human Resources to lead the Stoke Therapeutics Human Resource function. The successful candidate will be an active member of the Executive Team reporting directly to the CEO and will also be responsible for working closely with the Board of Directors and Compensation Committee. The successful candidate will possess a strong background in strategic hiring and selection, designing and implementing organizational structures, organizational and employee professional development, compensation strategy and total rewards programs.
Responsibilities:
- Partner with the executive team and senior management to align the organizational structure, practices, policies, and communication with the company’s strategy and culture.
- Evaluate and advise on the impact of strategic planning and growth initiatives on attracting, motivating, developing and retaining employees.
- Provide human resources technical advice, knowledge and leadership to others within the human resources group and the overall organization.
- Anticipate organizational issues and proactively provide practical recommendations of action.
- Lead the development and oversee the implementation of Stoke’s compensation philosophy and structure.
- Develop progressive and proactive compensation and benefits programs to motivate, incentivize and reward employees in a manner that fosters high performance and engagement.
- Create and implement programs to enhance organizational and employee development plans, including training programs, performance management systems and reward and recognition tools.
- Design and implement talent management programs including talent reviews and succession planning and the associated action plans.
- Manage and facilitate Stoke’s performance management process; ensure effective management and setting of goals throughout the organization appropriately tied to corporate goals and employee performance.
- Identify and help managers foster management practices that lead to outstanding performance for individuals and teams.
- Develop and oversee staffing and recruiting plans and efforts to identify and recruit top talent within and outside the company.
- Develop organizational plans that include organizational structure, job design and personnel forecasting.
- Oversee the development of human resources operations, systems and processes that will scale to support the organization as the company continues to grow and improve the overall operation and effectiveness of the company.
- Ensure that policies and procedures are consistently and equitably applied and that appropriate legal and compliance requirements are met while providing a proactive, positive employee relations climate.
- Provide leadership in interactions with the Compensation Committee of the Board of Directors, including coordinating with the Committee’s external compensation consultant, and partnering with the General Counsel and CFO to support analyses for and advice to the Compensation Committee.
- Partner with the Legal and Finance functions to insure HR processes and systems meet local, state, federal and corporate compliance requirements.
Qualifications & Experience:
- Undergraduate degree required, advanced degree strongly preferred with 15+ years of experience in human resources.
- Minimum 3 years’ experience as the top HR executive in a small to mid-sized company, or an independent division of a large company(preferably in biotech).
- Experience working with all levels of the organization, including a Board of Directors.
- Previous experience working in the pharmaceutical, biotechnology or life sciences industries is strongly preferred. In depth human resources experience working in staffing, compensation, benefits and training & development is highly desired.
Location: Bedford & Cambridge
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Associate Director, In Vitro Pharmacology
Stoke is seeking an enthusiastic and highly motivated pharmacologist to join the preclinical development group.
Primary Responsibilities:
- Establish internal in vitro pharmacology capabilities, including the use of a broad array of tissue culture models and assays for target evaluation.
- Develop assay systems to evaluate the functional impact of Stoke ASOs.
- Build new in vitro capabilities to support project goals.
- Manage a small team of scientists & cross-training of other scientists.
- Recruit personnel to support preclinical development of a growing pipeline.
- Manage and interact with external academic and CROs and facilitate technology transfer as needed.
- Collaborate extensively with discovery and other development project team members.
Qualifications & Experience:
- Ph.D. degree in molecular/cell biology or biochemistry with at least 9 years of post-graduate experience in developing assay systems for drug development.
- Previous experience with CNS and/or ocular drug development is a must.
- Previous experience with complex cell system assays e.g. iPSCs, 3D culture systems, organoids and other ex vivo culture systems.
- Deep knowledge of biological pathways and assay development.
- Previous experience managing teams.
- Strong organizational and record keeping skills.
- Strong presentation skills. Able to communicate to both internal and external audiences.
- Ability to work as a team player in a dynamic environment.
- Ability to lead from the bench.
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Associate Scientist/Scientist, Oligonucleotide Synthesis and Purification
Stoke is seeking an enthusiastic and highly motivated oligonucleotide chemist to join the growing chemistry group.
Primary Responsibilities:
- Synthesis, deprotection and purification of oligonucleotides from milligram to multigram scale to support all preclinical programs.
- Synthesis of oligonucleotide conjugates and oligonucleotides containing novel chemistries.
- Operation, maintenance and troubleshooting of oligonucleotide synthesis and purification equipment.
- Cross training in analytical characterization of chemically modified oligonucleotides for purity determination and impurity profiling.
- Conduct laboratory work in safe and efficient environment.
Qualifications & Experience:
- 5+ years industry experience with a B.Sc. degree, 3+ years of experience with an M.Sc. degree or 0-3 years with a Ph.D. in chemistry or a related field.
- Previous experience with ÄKTA Oligopilot and/or MerMade oligonucleotide synthesis platforms.
- Previous experience with oligonucleotide conjugation chemistry desired.
- Previous experience with analytical techniques for oligonucleotides and oligonucleotide conjugates is a plus.
- Strong organizational and recordkeeping skills.
- Excellent written and verbal communication skills.
- Ability to work as a team player in a dynamic environment and complete assignments to meet timelines.
Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.
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Director of IT
This position is primarily responsible for leading the design, implementation and management of IT systems and processes that support and integrate Stoke’s overall scientific and business technology platform.
Primary Responsibilities:
Specific duties and responsibilities include, but are not limited to:
- Implement the IT infrastructure and service capabilities strategy for current and future organizational needs.
- Lead the planning and implementation of IT initiatives as well as management of core day-to-day services.
- Monitor the availability, performance, capacity and utilization of IT and core application services and suggest necessary enhancements as appropriate.
- Manage IT vendors and consultants.
- Regularly and effectively communicate with key business and project stakeholders to understand requirements; keep them advised of project progress and overall IT services status.
- Maintain ongoing knowledge of industry trends to ensure the Company is leveraging the best and most efficient resources to meet Stoke’s evolving IT needs.
- Oversee IT security and compliance efforts, establishing controls and processes in support of data security, PHI, SOX and other relevant regulatory requirements.
- Establish and maintain IT policies and procedures.
- Maintain IT contingency plans.
- Manage overall budget for IT expenditures.
- Oversee maintenance of hardware and software used throughout the Company.
Required Qualifications & Experience:
- Degree in computer science or related technical discipline plus 10+ years of relevant experience managing IT infrastructure and services with prior experience in a biotech environment.
- Exceptional knowledge of IT infrastructure hardware, software (Windows, Linux, VMware, Active Directory, etc.) and SaaS (Office365, Mimecast, Centrify, etc.).
- Network administration certification.
- Experience with evaluating, implementing and managing infrastructure (storage/compute/networking), enterprise systems and core services.
- Prior experience in successfully implementing, utilizing and leveraging outsourcing strategies.
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Associate Director/Director, Clinical Data Management
Stoke Therapeutics is seeking a highly motivated and enthusiastic data management professional with hands-on expertise in clinical data management. The Associate Director/Director will be responsible for leading data management activities for one or more development programs and will serve as the highest point of escalation within data management per assigned programs(s). This role will report to the VP of Clinical Operations and be accountable for managing day-to-day operations of data management activities. The candidate will be responsible for oversight of Contract Research Organization (CRO) activities related to data management, including project management, vendor management and coordination of internal reviews.
Primary Responsibilities:
- Account for data management activities for Stoke clinical studies and oversee CRO data management activities that support ongoing clinical programs.
- Oversee data management activities for one or more products/programs, consisting of multiple clinical studies.
- Establish over time and maintain a “best in class” data management team, consisting of highly qualified and experienced data managers.
- Balance resources and ensure appropriate levels to support organization activities (current and future).
- Manage budgets and expenses, including budget projections.
- Support inspection readiness, quality compliance and training initiatives pertaining to Data Management activities.
- Create SOPs and standards for data management to support Stoke’s development programs.
- Develop the Data Management Plan (DMP) across programs and maintain throughout life cycle of study project to ensure DMP is followed according to study design and requirements.
- Review clinical research documents (e.g. protocols, case report forms, reports and statistical analysis).
- Review DB clinical trial data specifications, including eCRF design, user requirements, edit rules/checks, query logic and data validations.
- Review Data Transfer Agreement(s) (DTAs) between external data vendors and/or core labs.
- Reconcile electronic data transfers from vendor to sponsor.
- Oversee the User Acceptance Testing (UAT) by CRO and coordinate UAT of eCRF build and validation documents, included but not limited to editing documents, developing issue logs and creating the UAT summary report.
- Maintain/track EDC user management and other clinical databases across allocated clinical trials.
- Ensure clinical data within EDC is of high quality to support lock/unlock and freeze/unfreeze as appropriate for statistical review, interim review and/or final database lock, including but not limited to data reconciliation and/or coding.
- Accountable for eDiary, PRO and other electronic data collection on portable devices to make sure the design of data collection meets the scientific objective.
- Assist in defining and/or creating data listings, summary table validation, data specifications and/or process data transfers in preparation for statistical review and/or data management audit.
- Perform close-out audit, as specified, for closing of study trial in EDC or other clinical data management DBs.
- Assist in reconciling AE/SAE data in Safety DB and/or other data management DBs.
- Coordinate and communicate with DB vendors on a consistent basis to address Stoke’s clinical team’s requests, project plans and/or eCRF development activities.
- Participate in the preparation and presentation of data, when applicable.
- Ensure data system compliance by following the established guidelines of national and international regulatory authorities.
- Help to identify and troubleshoot operational problems, issues, obstacles and barriers for studies and programs; work with appropriate teams towards action and ensure resolution.
Qualifications & Experience:
- Bachelor’s degree or higher in a scientific or healthcare discipline preferred, with at least 5-10 years of progressive experience in data management within the biotech, pharmaceutical or CRO industry. Rare disease and neurology trial experience are highly desirable.
- Proficient in clinical data collection, cleaning and analysis for Phase I- IV clinical trials in the pharmaceutical industry.
- Experience working in an outsourced data management model.
- Knowledge of and experience with EDC databases, CDASH/SDTM standards, medical terminology, medical coding dictionaries and quality control processes.
- Familiarity with GCP, ICH and FDA requirements as applicable for clinical data management.
- Prior experience filing a BLA or NDA preferred.
- Ability to manage multiple initiatives and shifting priorities within a small company environment.
- Excellent interpersonal skills with the ability to work independently and collaboratively in a dynamic team environment.
- Strong experience in early phase drug development and rare diseases required.
Computer Skills:
- Microsoft applications (Outlook, Word, Excel, PowerPoint, Project).
- In-depth knowledge of clinical data management systems (e.g. Medidata Rave) required.
- SAS Viewer and other data visualization tools (Elluminate, Spotfire).
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Research Associate/Senior Research Associate, Biology
Stoke is seeking to hire a Research Associate or Senior Research Associate with a strong background in molecular and cell biology research. The successful candidate will work in a fast-paced and dynamic environment with a team of scientists and research associates to identify oligonucleotide-based drug candidates for the treatment of ocular and CNS diseases.
Primary Responsibilities:
- Work at the bench to support ongoing research efforts in screening and evaluating oligonucleotide-based drug candidates for ocular and CNS diseases.
- Perform cell and molecular biology techniques, including cell culture of primary cell lines, transfection, nucleofection, RNA preparation, primer design, qPCR, RT-PCR, western blotting and other project-specific assays, as necessary.
- Interpret experimental data and play an active role in assay development and planning of further experiments.
- Maintain accurate documentation of experiments in electronic lab notebooks (ELN).
- Present research findings at weekly group meetings and occasional company-wide and external meetings, as necessary.
- Work independently as well as collaborate with peers in a results-oriented research environment.
Qualifications & Experience:
- B.S/M.S. with a minimum of 3 years post-graduate experience in molecular and cell biology research, preferably in industry.
- Strong hands-on experience in RNA isolation techniques, mammalian cell culture and cell-based assays is a must.
- Prior drug development experience for CNS and/or ocular diseases is desirable, but not required.
- Experience in antisense-based target validation and mouse handling is a plus.
- Strong organizational and record-keeping skills, experience using electronic lab notebooks (ELN) is highly desirable.
- Strong analytical and presentational skills to be able to interpret and communicate experimental results in group and company-wide meetings.
Primary Location: Bedford, MA
Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.