Join Our Team
At Stoke, we are building a team of talented scientists, experienced drug developers and insightful leaders to address severe genetic diseases.
We are excited about breaking new scientific ground. This work is challenging, but we know we have the team to do it. We’re united around a common goal: to improve the lives of people living with severe genetic diseases.
Current openings
Stoke is always looking for individuals with a passion for developing precision medicines to tackle severe genetic diseases.
Senior Research Associate, In Vivo Pharmacology
Stoke is seeking an enthusiastic and highly motivated Senior Research Associate to join the In Vivo Pharmacology Department. This position is an opportunity to learn new techniques and concepts, be creative, and grow with a growing company.
Key Responsibilities:
- Design and execute studies to investigate the PK/PD and efficacy of drug candidates.
- Perform routine handling procedures and injections, monitor animal health, and collect tissues in mice.
- Perform behavioral experiments in animal models.
- Support the implementation of new animal models.
- Read and understand scientific literature.
- Analyze data, author technical reports, and document experiments in an electronic notebook.
- Participate and present at project team and departmental meetings.
- Collaborate across functional areas.
Required Skills & Experience:
- M.S. or B.S. in the field of biology related fields with 5-7+ years (B.S.) or 3-5+ years (M.S.) experience working in a biotechnology or pharmaceutical company or contract research organization.
- Experience working with animal disease models.
- Experience with animal behavioral assays.
- Strong organizational skills and attention to detail.
- Strong verbal and written communication skills.
- Creative thinking and working well in a team environment.
- Experience in neuroscience a plus.
- Experience in ophthalmology a plus.
We believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together, in person. As we emerge from the COVID-19 pandemic with a high rate of vaccination among our employees, we have begun a return to our physical work environments and resumed some business travel to engage with stakeholders when appropriate. We have established guidelines to allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. For some roles, the necessity of being physically present every day has and continues to be a priority to ensure continued progress with our important work for patients. We will continue to evaluate our practices as we move through this unique period.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position will be based in Bedford.
Travel:
No travel will be required for this position.
Benefits & Compensation:
At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP).
Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.
Apply Here
Clinical Supply Chain Manager
Key Responsibilities:
- Create, review, and update clinical supply and demand plans, and as appropriate use simulation tools to drive optimal clinical supply efficiency
- Communicate and update clinical supply requirements on study and program levels to project teams as required
- Monitor inventory levels at depots and clinical sites through the life of a trial; recommend and coordinate preventative actions to avoid potential supply issues
- Review clinical trial protocols and understand impact on supply
- Ensure regular interaction with cross-functional team members related to changes in supply configuration, trial design, enrollment timeline, manufacturing availability and regulatory requirements are considered
- Assist with label management for clinical product which includes creation of master label text, translations, and label proofs
- Manages the packaging Batch Record review and approval process with Quality Assurance
- Works closely with Quality Assurance and CMC to resolve temperature excursion
- Coordinate shipping oversight of clinical product to both US and ex-US locations
- Manage drug returns process and site close-out activities. Prepare drug reconciliation reports and see the process through to completion of destruction
- Communicate with external service providers/ partners on project requirements.
- Author or updates internal SOPs as required.
Required Skills & Experience:
- Bachelors in Life Sciences required.
- Minimum 3-5 years in Clinical Supply Management or a related field.
- At least 1-year direct experience in clinical supplies environment.
- Proficient knowledge of Microsoft Excel, PowerPoint and Project software required.
- Good understanding of clinical study design, execution, and impact of study drug supply.
- Demonstrated knowledge of clinical trial process from study start up through trial completion.
- Familiarity with various clinical trial designs (randomized, OLE, continued access).
- Demonstrated experience in inventory management and forecasting drug supply.
- Experience with IRT systems and managing the forecasting and planning of drug supply needs.
- General knowledge of GMP.
- Excellent communication and influencing skills, strong collaboration skills.
- Strong attention to detail.
- Ability to multi-task and manage complexity.
We believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together, in person. As we emerge from the COVID-19 pandemic with a high rate of vaccination among our employees, we have begun a return to our physical work environments and resumed some business travel to engage with stakeholders when appropriate. We have established guidelines to allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. For some roles, the necessity of being physically present every day has and continues to be a priority to ensure continued progress with our important work for patients. We will continue to evaluate our practices as we move through this unique period.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position will be based in Bedford.
Travel:
This position will require approximately 20% travel.
Benefits & Compensation:
At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP).
Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.
Apply Here
Purchasing Associate
Stoke is seeking an enthusiastic and highly motivated Purchasing Associate to join the Facilities and Engineering Department. This position reports to the Site Manager and is an opportunity to learn what it takes to support a busy biotechnology research lab from the standpoint of lab materials, including inventory management, purchasing, and receiving and site operations.
Key Responsibilities:
- Coordinate with lab researchers and G&A colleagues on the procurement of research materials, special orders and services
- Execute the Stoke purchasing process including obtaining competitive bids, coordinating with vendors, assigning cost centers and creating purchase orders
- Work with in-house contractor Fisher ULS on the lab consumables and cold reagents inventory management system
- Receive packages and deliver packages to the labs and cold storage locations
- Provide reception support. Greet visitors, vendors and delivery personnel and direct them accordingly.
- Support the Health Screening Questionnaire process for visitors and contractors.
- Sort and distribute mail and packages.
- Coordinate the maintenance of office equipment, including computers, copiers, printers and cafeteria appliances
- Maintain office and kitchen supplies
- Coordinate maintenance initiatives and small projects with landlord and construction contractors
- Additional projects as assigned.
Required Skills & Experience:
- High school diploma required.
- 1-3+ years’ experience in a site services and/or purchasing role.
- Familiarity with lab environment is a plus.
- Strong technical skills in MS Office required. Must be proficient in MS Excel.
- Demonstrated capability using financial concepts.
- Strong planning skills and follow through, strong interpersonal skills.
- Detail oriented and comfortable working in a fast-paced environment.
- Exceptional communication skills a must.
- Superior organizational skills and dedication to completing projects in a timely manner.
- Ability to maintain confidentiality.
We believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together, in person. As we emerge from the COVID-19 pandemic with a high rate of vaccination among our employees, we have begun a return to our physical work environments and resumed some business travel to engage with stakeholders when appropriate. We have established guidelines to allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. For some roles, the necessity of being physically present every day has and continues to be a priority to ensure continued progress with our important work for patients. We will continue to evaluate our practices as we move through this unique period.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position will be based in Bedford and may occasionally work from Cambridge.
Travel:
This position will require approximately 5% travel.
Benefits & Compensation:
At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP).
Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.
Apply Here
Paralegal
The Paralegal will to support Stoke’s legal department in a wide variety of corporate, contract, intellectual property, compliance, and legal operations matters. This position reports to the Deputy General Counsel and will work closely with all members of the legal department.
Key Responsibilities:
- Assist with corporate governance matters including preparation and maintenance of board and committee minutes, resolutions, consents and record books.
- Organize and maintain Intellectual Property (IP), compliance and other legal operations records and filings.
- Negotiate a variety of template-based contracts, including non-disclosure agreements, consulting agreements, material transfer agreements, data privacy addendums and other related agreements with Counsel support.
- Provide administrative support as necessary to the legal department, including setting up new law firms and vendors in new vendor and e-billing systems and managing billing and account inquiries for legal department vendors.
- Support ongoing company-wide initiatives, including policy development, template standardization and adoption of contract-related technologies.
Required Skills & Experience:
- Bachelor’s degree, Associate’s degree or paralegal certification is required.
- A minimum of 5 years of paralegal experience inhouse at biotech/biopharma company (can be combined with relevant experience at a law firm).
- Familiarity with IP docketing and management systems (such as CPI) and experience with PCT and foreign patent procedures is highly preferred.
- Outstanding attention to detail, organizational and strong record keeping skills are required for this role.
- A positive attitude and excellent interpersonal, oral and written communication skills are important.
- Ability to work independently and collaboratively and with a high level of confidentiality and discretion in handling of legal matters is critical for this role.
- Ability to multi-task and handle multiple assignments simultaneously in a fast-paced, deadline-driven environment.
- Proven ability to interface with outside counsel, vendors, collaborators, and internal functions at all levels is required.
- Willingness to grow and learn new responsibilities.
- Notary license in Massachusetts or willingness to get one.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA, and this position can be located at either.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Apply Here
Scientist, Discovery Biology
Stoke is seeking an enthusiastic, motivated Scientist. The candidate will be responsible for advancing our Platform capabilities and taking novel drug products into preclinical Proof-of-concept studies. The candidate will report to an Associate Principal Scientist in the Discovery Biology Group and support ongoing research efforts in developing oligonucleotide-based therapies. The candidate is expected to perform the following activities:
Key Responsibilities:
- Independently design and execute molecular assays to identify preclinical drug candidates targeting disease genes.
- Develop high-quality assays to inform disease target gene engagement in cell and animal models.
- Collaborate with internal groups to identify new Stoke disease targets.
- Work with CRO laboratories and external collaborators to support internal studies.
- Maintain accurate documentation of experiments in ELN.
- Author reports and contribute to manuscripts and patent filings.
- Present results at cross-functional team and lab meetings.
Required Skills & Experience:
- Ph.D. in molecular biology / related field, or, MS with 8 years or more of relevant experience working in the industry.
- Proven hands-on experience in vector cloning, cell culture, molecular biology, gene expression analysis and assay development.
- Ability to interpret and trouble shoot experiments independently.
- Excellent problem-solving skills and ability to work as a team player in a dynamic environment.
- Excellent communication and presentation skills required.
- Proficient in standard Microsoft Office tools: Word, Excel, and PowerPoint.
- Strong attention to detail and organizational skills.
- Prior RNA splicing and or gene therapy experience is a plus.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.
Travel:
This position may require 5% travel.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Apply Here
Senior Medical Director/Medical Director, Ophthalmology
This is an opportunity for a clinician to join a fast-growing company focused on precision medicines for genetic diseases. Join Stoke’s experienced and dedicated team to lead the development of transformative therapies for life threatening diseases. We are seeking a talented, independent, and motivated clinician to help design, implement and communicate clinical trials for our Ocular Disease programs. This position reports to the Chief Medical Officer.
Key Responsibilities Include:
- Lead clinical development activities for Stoke’s Autosomal Dominant Optic Atrophy program under supervision of the Chief Medical Officer. Establish and implement the Clinical Development Plan for the program.
- Collaborate closely with the Clinical Development Operations team and be accountable for all deliverables of clinical trials under his/her direct responsibility.
- Contribute to the clinical content of all clinical and regulatory documents for the Autosomal Dominant Optic Atrophy program, including study design, writing protocols, INDs, CTAs, investigator brochures, CRF’s, CSRs, annual IND reports, and clinical expert reports.
- Represents the clinical function at health authority interactions
- Contributes to disease area strategy planning to influence the future portfolio
- Participate in analysis of clinical data, including safety monitoring in collaboration with Pharmacovigilance.
- Develop and maintain relationships with key global opinion leaders and Principal Investigators.
- Organize and present at relevant clinical advisory boards and SMCs.
- Author manuscripts, publications, or other documents intended for external audiences.
- Help ensure Clinical Study Team compliance with FDA, EMA, PMDA, ICH and GCP guidelines and internal SOPs.
Required Experience:
- M.D. or M.D./Ph.D.
- Board certified or eligible in a medical or pediatric subspecialty preferred.
- Expertise in Ophthalmology is required.
- Strong record of basic and/or translational research productivity.
- At least 2 years of experience in clinical research in an industry setting.
- Experience with orphan diseases or oligonucleotide therapeutics is an advantage.
- Excellent written and verbal communication skills to meet the needs of varied audiences.
- Strong interpersonal skills commensurate with the need to work closely with partners, investigators, contractors, consultants, and team members across functions.
- Knowledge of FDA/EMA requirements, good clinical practices, and pharmaceutical clinical development.
- Ability to work independently and thrive in a fast-paced environment.
- Attention to detail, demand for high-quality work, and sense of passion and urgency to achieve goals and improve the lives of patients.
Travel:
This position will require approximately 25% travel, both domestic and international.
Location(s):
This position will be primarily located in Cambridge, MA, and may also work occasionally from Bedford, MA.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.