Join Our Team

Stoke is seeking to hire a Senior Research Associate with a strong background in cell and molecular biology research. The candidate will report to a Senior Scientist in the Platform Group and support ongoing research efforts in developing oligonucleotide-based therapies. The candidate is expected to perform the following activities:

• Work in aseptic conditions and maintain cultures of various cell types
• Screen and evaluate oligonucleotide-based drug candidates in cell-based assays
• Perform cell and molecular biology techniques such as RNA and protein isolation, RT-PCR, RT-qPCR, western blotting and other project-specific assays, as necessary
• Troubleshoot experiments, analyze and interpret data, participate in development of new assays
• Maintain accurate documentation of experiments in electronic lab notebook (ELN)
• Write technical reports and protocols, with guidance from supervisor
• Present research findings at group meetings and occasional company-wide and external meetings, as necessary
• Work independently as well as collaborate with peers in a result-oriented research environment

Skills & Experience:

• Senior Research Associate: B.S. with a minimum of 5+years post-graduate experience in molecular and cell biology research, preferably industry, or M.S. with a minimum of 2 years post-graduate experience in molecular and cell biology research, preferably industry
• Research Associate: B.S with a minimum of 2+ years post-graduate experience in molecular and cell biology research, preferably in industry
• Strong hands-on experience in RNA isolation techniques, mammalian cell culture and cell-based assays is a must
• Strong organizational and recordkeeping skills is desirable

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Primary Location: Bedford, MA

APPLY HERE

Stoke is seeking to hire a Research Associate, In Vivo Pharmacology. The candidate is expected to perform the following activities:

• Manage colony to support Stoke’s mice breeding program (including animal handling, data management, expansion breeding)
• Support the characterization and study of new animal models
• Support in vivo studies for multiple preclinical programs
• Perform in vivo procedures including dosing, body weights, tissue collection as well as downstream tissue processing such as RNA or protein extraction when required
• Follow IACUC protocols and operational procedures

Skills & Experience:

• Bachelor’s degree in pharmacology, animal science, or related discipline or RVT/LVT/CVT is required
• Demonstrated experience in rodent animal handling techniques
• Excellence in record keeping, laboratory organization, and communication skills is required
• Ability to work in a dynamic and cross-functional environment
• Willingness to learn and grow with a growing company
• Experience with rodent test article administration, surgery and/or tissue dissection skills is a plus
• Experience with rodent behavioral assessments is a plus
• Experience with tissue homogenization and RNA and protein extraction is a plus

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Primary Location: Bedford, MA

APPLY HERE

Stoke Therapeutics is seeking a Senior Director/Head of Intellectual Property to help build and manage Stoke’s internal patent preparation and prosecution capabilities to support the development of life-changing therapies using Stoke’s proprietary TANGO technology. In addition, this individual will have responsibility for managing intellectual property matters critical to Stoke’s success, counseling senior Stoke business leaders, managing IP disputes, patent portfolio strategy and management, outside counsel budgets and performance, IP competitive intelligence, and due diligence in support of business development transactions. The successful candidate will have significant depth of experience in diverse aspects of patent law practice, high technical competency in the life sciences, and will be adept at serving as a trusted business advisor. This position is based in Bedford or Cambridge, Massachusetts and will report directly to the Senior Vice President, Chief Legal Officer.

Primary Responsibilities:

• Lead the growth and management of Stoke’s internal patent preparation and prosecution capabilities, including developing procedures and best practices.
• Develop strategies to develop and protect Stoke’s intellectual property assets (including its portfolio of in-licensed foundational IP for TANGO, as well as new IP directed to therapeutic applications of TANGO, development candidates, research findings and other related subject matter).
• Analyze relevant third-party IP and advise on potential pathways for managing against risks.
• Implement and lead IP strategy for R&D project teams and establish positive working relationships with the R&D project teams by acting as their advisor on a variety of IP related issues.
• Oversee outside counsel in prosecuting worldwide patent applications, conduct patentability and freedom to operate assessments, and manage IP disputes.
• Lead IP due diligence, IP review and IP agreement negotiation support for Stoke’s business development activities working collaboratively with Business Development, CMC & Manufacturing, and external counsel.
• Develop and continually expand a thorough understanding of Stoke’s current and planned business activities, programs, competitors, and markets and keep abreast of developing legal trends, laws and regulations.
• Provide patentability and FTO opinions in support of R&D project teams and Business Development transactions.
• Assist in the negotiation and drafting of collaboration, licensing and other agreements.
• Educate and advise colleagues on global intellectual property issues.

Required Skills and Qualifications:

• JD or equivalent, registered patent attorney, and at least 10+ years post-law school experience.
• Ph.D. or scientific degree in a relevant biological science (e.g., Biochemistry, Molecular Biology).
• IP practice experience in both a law firm and a bio/pharmaceutical corporate setting.
• IP experience with antisense, oligonucleotides, gene therapies and/or DNA/RNA-based therapeutics a plus.
• Ability to work collaboratively with other Legal department members and with the R&D organization, and successfully manage outside counsel.
• Must have excellent interpersonal, decision making and communication skills.
• Must have ability to manage multiple competing demands and prioritize effectively.
• Must have exceptional intellectual capacity and agility; business counseling gravitas; and demonstrated capabilities in establishing business practices to manage legal and other risks.

Compensation: Compensation will be highly competitive for the industry and commensurate with experience.

Locations: Cambridge, MA / Bedford, MA

APPLY HERE

Primary responsibilities:

Stoke is seeking to hire a Research Associate or Senior Research Associate – In Vitro Pharmacology with a strong background in cell and molecular biology research. The candidate will report to a Senior Scientist in the In Vitro Pharmacology Group and support ongoing research efforts in developing oligonucleotide-based therapies for ocular and CNS diseases. The candidate is expected to perform the following activities:

• Work in aseptic conditions and maintain cultures of various cell types
• Screen and evaluate oligonucleotide-based drug candidates in cell-based assays
• Perform cell and molecular biology techniques such as RNA and protein isolation, RT-PCR, RT-qPCR, western blotting and other project-specific assays, as necessary
• Troubleshoot experiments, analyze and interpret data, participate in development of new assays
• Maintain accurate documentation of experiments in electronic lab notebook (ELN)
• Write technical reports and protocols, with guidance from supervisor
• Present research findings at group meetings and occasional company-wide and external meetings, as necessary
• Work independently as well as collaborate with peers in a result-oriented research environment

Skills & Experience:

• Senior Research Associate: B.S. with a minimum of 5+years post-graduate experience in molecular and cell biology research, preferably industry, or M.S. with a minimum of 2 years post-graduate experience in molecular and cell biology research, preferably industry
• Research Associate: B.S with a minimum of 3 years post-graduate experience in molecular and cell biology research, preferably in industry
• Strong hands-on experience in RNA isolation techniques, mammalian cell culture and cell-based assays is a must
• Prior drug development experience for ocular and/or CNS diseases is desirable
• Experience in antisense-based target validation is a plus
• Strong organizational and recordkeeping skills, experience using ELN is highly desirable

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Location: Bedford, MA

APPLY HERE

Stoke is seeking a Quality Control and Sample Management Specialist to join the Bioanalytical, DMPK and Biomarker Development group. The candidate will be responsible for all scientific documents quality control and sample management within the group. Specific responsibilities include but are not limited to:

• Conduct Quality Control (QC) review of Bioanalytical data (LC-MS/MS, ELISA, qPCR, etc.) generated in-house or at the CROs in support of regulated or non-regulated studies.
• QC protocols, Test methods, Bioanalytical plans, Validation protocols, Validation reports, Study reports and other study related documentation. Issue QC review observations and work closely with the PI/scientific staff to ensure proper documentation in a timely manner that meets all applicable regulatory requirements.
• Routinely conduct QC review of lab equipment and instrument logbooks, preventative maintenance and calibration documents.
• Responsible for packaging, shipping, receiving and accessioning of study samples and critical reagents in the Laboratory Information Management System (LIMS) following the laboratory’s SOPs.
• Assist in drafting or improving Bioanalytical Lab SOPs related to documentation, study samples or critical reagents shipment, receipt, accessioning and tracking.
• Assist Scientists in the lab when needed.

Skills & Experience:

• B.S. with a minimum of 5 years or M.S. with a minimum of two years of relevant experience working in pharmaceutical, CRO, Biotech or similar organizations
• Knowledge of GxP regulations and experience performing data review in a GxP environment.
• Must have excellent oral and written communication skills and demonstrated ability to work effectively in a fast-paced environment where multiple concurrent projects must be completed in a specified timeframe.
• Working knowledge of bioanalytical assays (LCMS/MS, immunoassays, etc.) is a plus.
• Proficient in standard Microsoft Office tools: Word, Excel, and PowerPoint.
• Strong attention to detail and organizations skills.
• Ability to take directions well and multi-task.
• Demonstrated proficiency with LIMS and sample management is preferred.

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Primary Location:Bedford, MA

APPLY HERE

Stoke is pioneering a new way to treat the underlying cause of severe genetic diseases by precisely upregulating protein expression. We develop antisense oligonucleotide medicines that increase gene expression to treat genetic epilepsies and other severe monogenic diseases, including genetic conditions affecting the central nervous system, eye, liver and kidney. Stoke is seeking an enthusiastic and highly motivated oligonucleotide chemist/analytical chemist to join the in-house oligonucleotide production team.

Primary Responsibilities:

• Oligonucleotide downstream processing to produce from milligram to multigram scale to support all preclinical programs
• Oligonucleotide formulation and analysis for in vitro and in vivo studies
• Operation, Maintenance and troubleshooting of oligonucleotide downstream process equipment and analytical instruments such as prep HPLC, TFF, lyophilizer, LC/MS, UV-Vis, Tm, Osmolality, pH etc.
• Independently analyze fractions, chemically modified oligonucleotides for purity determination and impurity profiling
• Conduct laboratory work in safe and efficient environment

Qualifications & Experience:

• For senior research associate, 5+ years relevant industry experience for B.Sc. or 2+ years for M.Sc. in Chemistry/Analytical Chemistry or related fields; for associate scientist, 7+ years relevant industry experience for B.Sc. or 5+ years for M.Sc. in those fields
• Previous experience in oligonucleotide downstream process including, but not limited to, purification, desalting and lyophilization
• Previous experience in analytical techniques for oligonucleotides and oligonucleotide-conjugates
• Previous experience in oligonucleotide formulation and analysis
• Previous experience with ÄKTA Oligopilot and/or MerMade oligonucleotide synthesis platforms is a plus
• Strong organizational and recordkeeping skills.
• Excellent written and verbal communication skills.
• Ability to work as a team player in a dynamic environment and complete assignments to meet timelines.

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Location: Bedford, MA

APPLY HERE

Stoke is seeking an enthusiastic and highly motivated Systems Administrator to join the Information Technology team. The Systems Administrator will be the primary contact for day to day IT operations and will be responsible for supporting workstations, servers and network, phones, and Office 365 and other cloud platforms. This position reports to the Senior Director of IT and will be based out of our Bedford and Cambridge offices.

Essential Duties and Responsibilities:

• Provide helpdesk support resolving problems relating to computers, printers, network services, and business applications. Collaborate with and manage MSP and its engineers to provide best support experience for end users.
• Participates in monitoring, investigation, and problem resolution of systems, network, and security.
• Responsible for desktop engineering discipline – develops and continuously improves installation and configuration procedures, tools, standards, and documentation for end user computer and software deployments.
• Administer and deploy cloud applications and services: Office 365, VoIP, Egnyte, Mimecast, ELN, Druva, etc.
• Manage and build servers and network services: backups, Active Directory, DNS, DHCP, and endpoint management tools.
• Support lab computers used to run lab instruments and data acquisition.
• Responsible for computer patching process, including testing and documentation.
• Owns hardware and software license management and procurement.
•  Helps with research, development, and maintenance and documentation of innovative, repeatable, and automated approaches for internal IT processes and tasks to increase overall quality of IT service including escalation guidelines, ticket categorization and IT helpdesk knowledge base.
• Create and maintain end user/IT documentation, procedures, and policies.

Qualifications:

• 5 years proven experience in an IT department of a fast paced, high growth company preferably in the Biotechnology and Pharmaceutical industry.
• Degree in MIS, Computer Science or Engineering or related studies; relevant experience may be considered in lieu of a degree.
• A positive and pleasant demeanor and clear, concise communications skills.
• Think and work methodically, independently, and prioritize to resolve problems and manage projects.
• Attention to detail and accuracy and strong analytical ability.
• Solid, hands-on experience with Windows OSes, Office 365, Intune or other MDM platforms, Active Directory, Egnyte, VMware, Veeam, Druva.
• Fluent understanding of networks (VLANs, routing, VPNs, network services (DNS, DHCP), security concepts.
•  Strong analytical ability, translating requirements into a logical architecture.
• Professional certifications and experience with Linux a plus.

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Locations: Bedford, MA and Cambridge, MA

APPLY HERE

This position will oversee all medicinal chemistry activities from Hit identification to clinical proof-of-concept. This position is responsible for creating and executing a chemistry strategy to support both discovery and early development activities, including the identification of key areas for investment, building appropriate internal and external capabilities, and communicating the company’s chemistry strategy both internally and to the external scientific community.

Duties & Responsibilities:

Specific duties and responsibilities include, but are not limited to:

• Create and execute overall chemistry plan to ensure robust, cost-effective support of company discovery and development portfolio
• Recruit high-quality chemistry personnel to support chemistry plan
• Oversee design and manufacture of oligonucleotides to support all stages of discovery and lead optimization for preclinical programs
• Evaluate and select CROs and CMOs to support key preclinical chemistry activities
• Oversee both internal chemistry team and external preclinical chemistry resources
• Oversee CMC activities for all preclinical programs
• Assist in authoring of CMC sections of regulatory submissions
• Regularly assess developments in the field of oligonucleotide therapeutics and identify areas for future investment
• Communicate chemistry strategy and activities to senior management and Board of Directors on regular basis
• Serve as primary liaison with corporate partners on all issues related to medicinal chemistry
• Present updates of Stoke platform and chemistry developments at key scientific conferences
• Willingness to live and work in Boston area
• Occasional travel for oversight of external CROs is expected

Required Qualifications & Experience:

• A Ph.D. in organic chemistry or medicinal chemistry or related discipline
• At least 15 years of industry experience, including at least 10 years in oligonucleotide therapeutics
• Demonstrated success in the design, medicinal chemical optimization, and formulation/delivery of oligonucleotide therapeutics
• Previous experience in the GMP manufacture of oligonucleotide therapeutics, either directly or through a contract manufacturer, is a plus
• Previous experience authoring CMC sections of regulatory submissions is a plus
• Proven experience managing multiple direct reports
• Strong presentation skills to facilitate communication with both internal and external audiences
• Strong decision-making skills to facilitate execution of timelines
• Ability to work as a team player

Location: Bedford & Cambridge

Apply Here