Join Our Team
At Stoke, we are building a team of talented scientists, experienced drug developers and insightful leaders to address severe genetic diseases.
We are excited about breaking new scientific ground. This work is challenging, but we know we have the team to do it. We’re united around a common goal: to improve the lives of people living with severe genetic diseases.
Current openings
Stoke is always looking for individuals with a passion for developing precision medicines to tackle severe genetic diseases.
Director, Medical Affairs & Medical Communications
Stoke is seeking an enthusiastic and highly motivated Director to join the Medical Affairs group. The successful candidate will be responsible for:
Key Responsibilities Include:
- Leading the development and execution of the global Medical and Scientific communication plans for STK-001 and other Stoke pipeline programs.
- Leading the development and execution of global external Medical and Scientific stakeholder engagement plans.
- Proactively incorporating the voices of patients, families, and physicians, as well as the needs of customers, including payers, in the development of medical strategies and tactics.
- In collaboration with Corporate Affairs, developing and maintaining relationships with Patient Advocacy Groups associated with Stoke pipeline programs to include communications, study participation requests, educational material.
- Setting the Medical Affairs strategy and overseeing its successful execution
- Work cross-functionally to ensure alignment of Medical Affairs activities with Corporate strategy and goals. Overseeing all medical education activities and events, including conferences, scientific symposium, CME and other scientific programs.
- Designing and implementing processes and standards for Medical Affairs in the company including Compliance requirements.
- Participating in strategic long-range corporate planning involving Medical Affairs.
- Establishing and building a leading Medical Affairs function to support Stoke’s immediate needs with a vision for the future.
Required Experience:
- PhD, PharmD with 3 to 5 years’ experience of pharmaceutical industry experience in Medical Affairs or Medical Communications required.
- CNS disease experience is preferred.
- Strong scientific background required.
- Ability to understand and effectively communicate scientific and medical information to both internal and external stakeholders.
- Knowledge of regulatory and compliance requirements.
- Strong interpersonal skills and project management skills.
- Ability to adapt to change while maintaining strategic focus.
Travel:
Approximately 20-30% of this position will require travel.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Location(s):
This position will primarily be in Cambridge, MA, and may also work occasionally from Bedford, MA.
Stoke operates sites in Bedford, MA, and Cambridge, MA. The individual in this role will be an integral contributor to the team, working closely with their manager and members of the executive leadership team, and may be based primarily in one of the two locations with the ability to work from the other location as the need arises.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.
Apply Here
Scientist, Bioanalytical/ADME
Stoke is seeking an enthusiastic, collaborative, and experienced Bioanalytical Scientist to join the Bioanalytical, DMPK and Biomarker Development group.
Key Responsibilities:
- Develop high-quality assays to quantitate oligonucleotides in biological matrices to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates.
- Responsible for sample analysis to support PK/PD and other non-clinical studies, interpret results and report data to support INDs/CTAs.
- Participate in the management of CROs in the conduct of in vitro/in vivo ADME studies.
- Partner with and support Toxicology and Research.
- Establish oligonucleotide stability profiling and metabolite identification.
- Work with CRO laboratories to transfer, qualify/validate bioanalytical assays, and support assay implementation.
- Write SOPs and other technical reports as needed.
- Present results at cross-functional team and lab meetings.
- Maintain accurate documentation of experiments in ELN.
- Help maintain the bioanalytical lab and keep the instruments running properly.
Required Skills & Experience:
- Bachelor’s degree with 10+ years of experience, or Master’s degree with 8+ years of post-graduate experience, or Ph.D. with a minimum of 2 years of relevant experience working in industry.
- Strong knowledge of drug metabolism, ADME concepts and bioanalytical principles is required. Experience in metabolism aspect of oligonucleotides is highly desirable.
- Good understanding of bioanalytical assay development, validation, and implementation.
- Proven hands-on experience in various bioanalytical formats e.g. LC-MS/MS (Sciex/Thermo), HELISA, MSD etc.
- Excellent problem-solving skills and ability to work as a team player in a dynamic environment.
- Excellent communication and presentation skills required.
- Proficient in standard Microsoft Office tools: Word, Excel, and PowerPoint.
- Strong attention to detail and organizations skills.
- Prior drug development experience in nucleic acids-based therapeutics is highly desirable.
- Basic understanding of GLP with ICH and FDA Guidance is a plus.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.
Apply Here
Senior Scientist/Scientist, Biomarker Development
Stoke is seeking an enthusiastic, collaborative, and experienced Biomarker Development Scientist to join the Bioanalytical, DMPK and Biomarker Development group. The candidate will be responsible for biomarker discovery, assay development and implementation.
Key Responsibilities:
- Support clinical biomarker discovery efforts to inform target engagement and pharmacodynamics in patients.
- Evaluate a variety of platforms including immunoassays and LCMS and implement “fit for purpose” assays, as necessary.
- Collaborate with clinical operations to ensure biomarker testing and data generation is compliant with all regulatory requirements in clinical studies.
- Participate in clinical biomarker sub team that includes representatives from research, pharmacology and DMPK functions.
- Develop high-quality assays to quantitate biomarkers in biofluids in preclinical and clinical samples, interpret results and report data to support biomarker discovery efforts.
- Characterize/evaluate critical reagents including protein reference materials, antibodies, and reagents to ensure quality and stability.
- Work with CRO laboratories to transfer, qualify/validate bioanalytical assays, and support assay implementation.
- Prepare protocols and standard operating procedures (SOPs).
- Present results at cross-functional team and lab meetings.
- Maintain accurate documentation of experiments in ELN.
- Help maintain the bioanalytical lab and keep the instruments running properly.
Required Skills & Experience:
- Ph.D. with a minimum of 2 years of relevant experience working in the industry.
- Good understanding of bioanalytical and biomarker assay development, validation, and implementation.
- Proven hands-on experience in biomarker discovery and development using a variety of platforms e.g. qPCR, Western blots, LCMS, MSD-ECL, Luminex, Singulex, Simoa/Quanterix etc.
- Excellent problem-solving skills and ability to work as a team player in a dynamic environment.
- Excellent communication and presentation skills required.
- Proficient in standard Microsoft Office tools: Word, Excel, and PowerPoint.
- Strong attention to detail and organizations skills.
- Familiarity with regulatory expectations (FDA and EMA) and industry’s best practices in validation of biomarker assays is highly desired.
- Prior drug development experience in nucleic acids-based therapeutics is a plus.
- Prior experience in testing biological matrices for PK/PD evaluation is a plus.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.
Apply Here
Director of Communications & Investor Relations
The Associate Director/Director of Communications & Investor Relations will play a critical role in supporting and executing communications activities related to the company’s mission, strategic objectives, and progress. Reporting to the Vice President, Head of Corporate Affairs, this individual will play a leadership role in the company’s communications, with a particular focus on the investor relations and communications to current and prospective shareholders and sell-side analysts. S/He will be responsible for developing and executing a comprehensive investor relations strategy to support the company’s goal of ensuring an accurate understanding of the company’s vision, strategy and its fair valuation. Serving as second in command to the VP, this person will contribute to many aspects of the Corporate Affairs function. S/He will assist with a broad scope of Corporate Affairs activities, including those related to Internal and External communications and Patient Advocacy.
Key Responsibilities Include:
- Collaborate with the VP, Head of Corporate Affairs to develop and implement an investor relations strategy and plans.
- Lead the development and implementation of the company’s Investor Relations strategy and execution, including day-to-day management of investor interactions and events (corporate calendar, non-deal roadshows, conference management, briefing materials, corporate presentations, bus tours, etc.).
- Work closely with executive leadership to establish the optimal mix of shareholders for Stoke at each stage of its evolution through strategic and thoughtful targeting initiatives.
- Work closely with cross-functional leaders and colleagues to stay current on company progress to guide investor-focused communications and then work collaboratively on materials development such as press releases, backgrounders, fact sheets, website content, Q&As, presentations, call scripts, executive talking points, social media posts, internal communications and intranet content.
- Serve as a primary point of contact for all investor inquiries; cultivate and maintain strong relationships with investors (current and potential future), sell-side research analysts, media and other key stakeholders. Provide timely, consistent, compliant and accurate responses.
- Effectively anticipate investor concerns, questions and needs by keeping current on the industry and competitive landscape while maintaining a deep understanding of Stoke’s business and progress.
- Monitor and assess market and sector dynamics as well as all investment research (including models and estimates) on Stoke and its industry peers. Provide data and metrics-driven insights into the market and competitive landscape, using the information to counsel Stoke management and guide investor communications and activities.
- Continuously evaluate Stoke’s performance with investors and use data as well as keen observation and critical thinking skills to continuously improve Stoke’s ongoing investor engagement.
- Partner closely with Finance, Legal and other departments to ensure accurate and appropriate information for financial reporting, including as part of quarterly communications and regular SEC filings.
- Serve as an internal resource for communications counsel and assist with the departmental activities including helping maintain the website, social media channels, executive visibility and patient advocacy efforts.
- Manage external agencies and vendors that are supporting investor communications and activities.
Required Experience:
- Bachelor’s Degree, preferably in Journalism, Communications, Business, Finance, Accounting or a related field. Post-graduate degree a plus.
- 7+ years of experience in the biotech or pharmaceutical industry working for/on behalf of publicly-traded, high-growth companies. Experience in investor relations, corporate communications, corporate strategy, equity research, investment banking and/or finance.
- Excellent communications skills: written, verbal and presentation delivery.
- Demonstrated ability to simplify complex information and distill it into clear, concise and simple messages that help to effectively communicate the company story.
- Results-driver with proven ability to identify and analyze business dynamics to develop and implement plans to support investor relations activities.
- Strategic thinker and problem solver; intellectually curious and perceptive; able to identify interdependencies and connections across the business; a critical thinker.
- Comfortable in a fast-moving, rapidly changing environment; able to establish structure and process when needed; consistently prioritizes high-impact projects; calm under pressure; works with a sense of purpose and urgency.
- Appreciation for laws and regulations governing the industry and publicly-traded company communications and investor engagement activities.
- Holds self and others to a high standard of ethics and integrity. Maintains confidentiality, exercises good judgment and discretion.
- Demonstrated ability to lead, influence and collaborate across the organization and at all levels, both internally and externally.
- Able to work independently with minimal supervision.
Travel:
Once investor and other meetings and conferences return to being conducted in-person, it is anticipated that approximately 25-35% of this individual’s time will be spent traveling, primarily to New York and other areas with high investor concentrations as well as other medical conferences and industry meetings.
Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. The individual in this role will be an integral contributor to the team, working closely with their manager and members of the executive leadership team, and may be based primarily in one of the two locations with the ability to work from the other location as the need arises.
Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.