Join Our Team

At Stoke, we are building a team of talented scientists, experienced drug developers and insightful leaders to address severe genetic diseases.

We are excited about breaking new scientific ground. This work is challenging, but we know we have the team to do it. We’re united around a common goal: to improve the lives of people living with severe genetic diseases.

Current openings

Stoke is always looking for individuals with a passion for developing precision medicines to tackle severe genetic diseases.

Senior Clinical Operations Associate

Opportunity Overview:

Stoke is seeking an enthusiastic and highly motivated Sr. Clinical Operations Associate to join the Clinical Operations group. The successful candidate will be responsible for:

Collect, file and/or track clinical trial associated regulatory documents.
Coordinate and track the distribution and subsequent retrieval of clinical documents, including but not limited to; protocols, protocol amendments, IBs, ICF’s, monitoring visits reports.
Fully understands the need for and importance of being inspection ready and diligently follows Stoke Clinical Operations SOPs; Maintains all documentation and identifies and communicates if there are gaps
Maintenance of the internal file structure according to ICH-GCP, and company SOPs.
Assist in the preparation of study related documents, i.e. ICF, clinical trial tools, trackers & templates.
Accountable for study level tracking as assigned by the Clinical Operations Manager; e.g. monitor visit tracking, clinical trial equipment; IP supply and sample tracking
Responsible for working with Regulatory Affairs to track all safety letters to Investigators according to timelines
Perform administrative tasks; Create agendas and record team meeting minutes and tracking of action items to support the Clinical Operations Department under the direction of the assigned Clinical Operations Manager.
Assist the Clinical Operations Manager with timeline development and/or review.
Act as central point of communication for trial team as well as study sites and vendor personnel.
Develops knowledge of sample collection and analysis process at the study level and may perform reconciliation and/or tracking of these activities
Under the guidance and direction of the Clinical Operations Manager, interfaces with other Stoke functions to coordinate relevant and timely exchange of information / materials to support clinical trials delivery within the drug development process

Qualifications & Experience:

Bachelor’s degree in life sciences or healthcare related field.
3-5 years’ experience in a clinical research related position.
Strong computer skills including knowledge of Excel, Word, PowerPoint and Outlook and MS Project.
Solid understanding of the responsibilities and needs of other functions in a clinical trial.
Proven ability to work independently and effectively handle multiple priorities in a fast-paced environment.
Ability to maintain confidentiality of proprietary information expected.
A team player that takes initiative is a must.
Excellent interpersonal skills, strong organizational skills, and effective communication across all levels within an organization.
Proficient written and verbal communication skills.
Position may require some travel.

Benefits & Compensation:
Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Location(s):
Candidate will have the flexibility to travel to the Bedford, Ma and Cambridge, MA locations.

APPLY HERE

Senior Scientist – In vivo Pharmacology

Program Manager/Senior Program Manager

Stoke Therapeutics is seeking an enthusiastic and highly motivated Program Manager/Senior Program Manager to join the Program Development Team. The successful candidate will be responsible for:

Define project objectives, requirements, and assumptions necessary to structure a project or activity.
Plan, schedule, and control project activities to fulfill objectives and satisfy project requirements.
Develop and drive integrated project plans, aligning project tactics with project strategy.
Conduct team meetings with internal and external stakeholders; develop agenda, meeting minutes, and action items for team members.
Lead risk management within project teams, ensuring risks have appropriate mitigation and contingency plans.
Ensure successful scientific execution of individual projects and identifies opportunities for synergies across the portfolio.
Ensure collaboration agreements are executed in accordance with contracts. Coordinate alliance communications, meetings, and decision making.

Qualifications & Experience:

The ideal candidate for this position will possess the following:

Bachelor’s degree in a science or engineering discipline.
5+ years of industry experience in the pharmaceutical, biotechnology, diagnostics, and/or medical device industries.
3+ years of project management experience related to early Research and development
Demonstrated attention to detail and excellence in project management and effectively managing multiple alliances/projects/priorities
Experience in Alliance Management a plus
Sound technical aptitude and proven ability to grasp general knowledge of multiple disciplines and technologies with superior computer usage skills.

Benefits:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Compensation:

Compensation will be highly competitive for the industry and directly commensurate with experience.

Location(s): Bedford, Massachusetts

APPLY HERE

Director/Sr. Director, Head of Investor Relations

Stoke Therapeutics is seeking a Director/Sr. Director, Head of Investor Relations, will be responsible for leading the development and execution of Stoke’s strategic planning and engagement with the investment community to support the company’s goal of ensuring an accurate understanding of the company’s vision, strategy and its fair valuation. As the primary point of contact for all Stoke investor relations, s/he will establish and maintain credibility and trust with the investment community, including current shareholders, prospective shareholders and sell-side financial analysts. This position will report to the Vice President, Head of Corporate Affairs and work closely with members of the executive team, providing guidance on all investor interactions.

Key Responsibilities Include:

Required Experience:

Bachelor’s Degree, preferably in Business, Finance, Accounting or a related field. Post-graduate degree a plus.
10+ years of investor relations in a publicly-traded biotech or pharmaceutical company, preferably for a high-growth organization. Ideal candidate has experience in investor relations, corporate communications, corporate strategy, equity research, investment banking and/or finance.
Established relationships with industry analysts and institutional investors with a demonstrated ability to successfully manage these relationships. Has a reputation as a trusted IR professional.
Excellent communications skills: written, verbal and presentation delivery. Experience in financial writing.
Demonstrated ability to effectively influence, with and without authority.
Demonstrated ability to simplify complex information and synthesize and distill information into clear, concise and simple messages that help to effectively communicate the company story.
Results-driver with proven ability to identify and analyze business dynamics to develop and implement plans to support investor relations activities.
Strategic thinker and problem solver; intellectually curious and perceptive; able to identify interdependencies and connections across the business; a critical thinker.
Comfortable in a fast-moving, rapidly changing environment; able to establish structure and process when needed; consistently prioritizes high-impact projects; calm under pressure; works with a sense of purpose and urgency.
Understanding of laws and regulations governing the industry and publicly-traded company communications and investor engagement activities.
Holds self and others to a high standard of ethics and integrity. Maintains confidentiality, exercises good judgment and discretion.
Demonstrated ability to lead, influence and collaborate across the organization and at all levels, both internally and externally.
Able to work independently with minimal supervision.

Travel:

Approximately 20-30% of this individual’s time will be spent traveling, primarily to New York and other areas with high investor concentrations as well as annual investor conferences.

Benefits & Compensation:

Location(s): This position will primarily be located in Bedford, Mass., and will also work from Cambridge, Mass.

APPLY HERE

Sr Director, Head of Intellectual Property

Stoke Therapeutics is seeking a Senior Director/Head of Intellectual Property to help build and manage Stoke’s internal patent preparation and prosecution capabilities to support the development of life-changing therapies using Stoke’s proprietary TANGO technology. In addition, this individual will have responsibility for managing intellectual property matters critical to Stoke’s success, counseling senior Stoke business leaders, managing IP disputes, patent portfolio strategy and management, outside counsel budgets and performance, IP competitive intelligence, and due diligence in support of business development transactions. The successful candidate will have significant depth of experience in diverse aspects of patent law practice, high technical competency in the life sciences, and will be adept at serving as a trusted business advisor. This position is based in Bedford or Cambridge, Massachusetts and will report directly to the Senior Vice President, Chief Legal Officer.

Primary Responsibilities:

Lead the growth and management of Stoke’s internal patent preparation and prosecution capabilities, including developing procedures and best practices.
Develop strategies to develop and protect Stoke’s intellectual property assets (including its portfolio of in-licensed foundational IP for TANGO, as well as new IP directed to therapeutic applications of TANGO, development candidates, research findings and other related subject matter).
Analyze relevant third-party IP and advise on potential pathways for managing against risks.
Implement and lead IP strategy for R&D project teams and establish positive working relationships with the R&D project teams by acting as their advisor on a variety of IP related issues.
Oversee outside counsel in prosecuting worldwide patent applications, conduct patentability and freedom to operate assessments, and manage IP disputes.
Lead IP due diligence, IP review and IP agreement negotiation support for Stoke’s business development activities working collaboratively with Business Development, CMC & Manufacturing, and external counsel.
Develop and continually expand a thorough understanding of Stoke’s current and planned business activities, programs, competitors, and markets and keep abreast of developing legal trends, laws and regulations.
Provide patentability and FTO opinions in support of R&D project teams and Business Development transactions.
Assist in the negotiation and drafting of collaboration, licensing and other agreements.
Educate and advise colleagues on global intellectual property issues.

Required Skills and Qualifications:

JD or equivalent, registered patent attorney, and at least 10+ years post-law school experience.
Ph.D. or scientific degree in a relevant biological science (e.g., Biochemistry, Molecular Biology).
IP practice experience in both a law firm and a bio/pharmaceutical corporate setting.
IP experience with antisense, oligonucleotides, gene therapies and/or DNA/RNA-based therapeutics a plus.
Ability to work collaboratively with other Legal department members and with the R&D organization, and successfully manage outside counsel.
Must have excellent interpersonal, decision making and communication skills.
Must have ability to manage multiple competing demands and prioritize effectively.
Must have exceptional intellectual capacity and agility; business counseling gravitas; and demonstrated capabilities in establishing business practices to manage legal and other risks.

Compensation: Compensation will be highly competitive for the industry and commensurate with experience.

Locations: Cambridge, MA / Bedford, MA

APPLY HERE

Senior Research Associate/Associate Scientist – Oligonucleotide downstream processing

Stoke is pioneering a new way to treat the underlying cause of severe genetic diseases by precisely upregulating protein expression. We develop antisense oligonucleotide medicines that increase gene expression to treat genetic epilepsies and other severe monogenic diseases, including genetic conditions affecting the central nervous system, eye, liver and kidney. Stoke is seeking an enthusiastic and highly motivated oligonucleotide chemist/analytical chemist to join the in-house oligonucleotide production team.

Primary Responsibilities:

Oligonucleotide downstream processing to produce from milligram to multigram scale to support all preclinical programs
Oligonucleotide formulation and analysis for in vitro and in vivo studies
Operation, Maintenance and troubleshooting of oligonucleotide downstream process equipment and analytical instruments such as prep HPLC, TFF, lyophilizer, LC/MS, UV-Vis, Tm, Osmolality, pH etc.
Independently analyze fractions, chemically modified oligonucleotides for purity determination and impurity profiling
Conduct laboratory work in safe and efficient environment

Qualifications & Experience:

For senior research associate, 5+ years relevant industry experience for B.Sc. or 2+ years for M.Sc. in Chemistry/Analytical Chemistry or related fields; for associate scientist, 7+ years relevant industry experience for B.Sc. or 5+ years for M.Sc. in those fields
Previous experience in oligonucleotide downstream process including, but not limited to, purification, desalting and lyophilization
Previous experience in analytical techniques for oligonucleotides and oligonucleotide-conjugates
Previous experience in oligonucleotide formulation and analysis
Previous experience with ÄKTA Oligopilot and/or MerMade oligonucleotide synthesis platforms is a plus
Strong organizational and recordkeeping skills.
Excellent written and verbal communication skills.
Ability to work as a team player in a dynamic environment and complete assignments to meet timelines.

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Location: Bedford, MA

APPLY HERE

System Administrator

Stoke is seeking an enthusiastic and highly motivated Systems Administrator to join the Information Technology team. The Systems Administrator will be the primary contact for day to day IT operations and will be responsible for supporting workstations, servers and network, phones, and Office 365 and other cloud platforms. This position reports to the Senior Director of IT and will be based out of our Bedford and Cambridge offices.

Essential Duties and Responsibilities:

Provide helpdesk support resolving problems relating to computers, printers, network services, and business applications. Collaborate with and manage MSP and its engineers to provide best support experience for end users.
Participates in monitoring, investigation, and problem resolution of systems, network, and security.
Responsible for desktop engineering discipline – develops and continuously improves installation and configuration procedures, tools, standards, and documentation for end user computer and software deployments.
Administer and deploy cloud applications and services: Office 365, VoIP, Egnyte, Mimecast, ELN, Druva, etc.
Manage and build servers and network services: backups, Active Directory, DNS, DHCP, and endpoint management tools.
Support lab computers used to run lab instruments and data acquisition.
Responsible for computer patching process, including testing and documentation.
Owns hardware and software license management and procurement.
Helps with research, development, and maintenance and documentation of innovative, repeatable, and automated approaches for internal IT processes and tasks to increase overall quality of IT service including escalation guidelines, ticket categorization and IT helpdesk knowledge base.
Create and maintain end user/IT documentation, procedures, and policies.

Qualifications:

5 years proven experience in an IT department of a fast paced, high growth company preferably in the Biotechnology and Pharmaceutical industry.
Degree in MIS, Computer Science or Engineering or related studies; relevant experience may be considered in lieu of a degree.
A positive and pleasant demeanor and clear, concise communications skills.
Think and work methodically, independently, and prioritize to resolve problems and manage projects.
Attention to detail and accuracy and strong analytical ability.
Solid, hands-on experience with Windows OSes, Office 365, Intune or other MDM platforms, Active Directory, Egnyte, VMware, Veeam, Druva.
Fluent understanding of networks (VLANs, routing, VPNs, network services (DNS, DHCP), security concepts.
Strong analytical ability, translating requirements into a logical architecture.
Professional certifications and experience with Linux a plus.

Compensation: Compensation will be highly competitive for the industry and directly commensurate with experience.

Locations: Bedford, MA and Cambridge, MA

APPLY HERE

Vice President of Medicinal Chemistry

This position will oversee all medicinal chemistry activities from Hit identification to clinical proof-of-concept. This position is responsible for creating and executing a chemistry strategy to support both discovery and early development activities, including the identification of key areas for investment, building appropriate internal and external capabilities, and communicating the company’s chemistry strategy both internally and to the external scientific community.

Duties & Responsibilities:

Specific duties and responsibilities include, but are not limited to:

Create and execute overall chemistry plan to ensure robust, cost-effective support of company discovery and development portfolio
Recruit high-quality chemistry personnel to support chemistry plan
Oversee design and manufacture of oligonucleotides to support all stages of discovery and lead optimization for preclinical programs
Evaluate and select CROs and CMOs to support key preclinical chemistry activities
Oversee both internal chemistry team and external preclinical chemistry resources
Oversee CMC activities for all preclinical programs
Assist in authoring of CMC sections of regulatory submissions
Regularly assess developments in the field of oligonucleotide therapeutics and identify areas for future investment
Communicate chemistry strategy and activities to senior management and Board of Directors on regular basis
Serve as primary liaison with corporate partners on all issues related to medicinal chemistry
Present updates of Stoke platform and chemistry developments at key scientific conferences
Willingness to live and work in Boston area
Occasional travel for oversight of external CROs is expected

Required Qualifications & Experience:

A Ph.D. in organic chemistry or medicinal chemistry or related discipline
At least 15 years of industry experience, including at least 10 years in oligonucleotide therapeutics
Demonstrated success in the design, medicinal chemical optimization, and formulation/delivery of oligonucleotide therapeutics
Previous experience in the GMP manufacture of oligonucleotide therapeutics, either directly or through a contract manufacturer, is a plus
Previous experience authoring CMC sections of regulatory submissions is a plus
Proven experience managing multiple direct reports
Strong presentation skills to facilitate communication with both internal and external audiences
Strong decision-making skills to facilitate execution of timelines
Ability to work as a team player

Location: Bedford & Cambridge