Join Our Team

Stoke is seeking an enthusiastic and highly motivated oligonucleotide chemist to join the chemistry group. The successful candidate will be responsible for:

• Identifying problems / deficiencies in oligonucleotides of interest for therapeutic optimization and then designing new oligonucleotides as well as implementing work plans to affect their solution resulting in broad utility across multiple disciplines
• Assuming scientific leadership and optimizing the processes for:
  • Internal oligonucleotide synthesis capability, including the set-up of new synthesis and purification equipment.
  • Synthesis and purification of oligonucleotides from milligram to multigram scale.
  • Synthesis of oligonucleotide conjugates and oligonucleotides containing novel chemistries.
  • Sourcing of raw materials and all other reagents needed for oligonucleotide synthesis.
• Cross-training of other chemistry personnel in oligonucleotide synthesis and purification methodology.
• Interacting with external oligonucleotide synthesis CMOs to manage orders, assist with troubleshooting, and facilitate technology transfer as needed.
• Collaborating extensively with discovery and development project teams.

Required Skills & Experience:

• Ph.D. degree in chemistry or biochemistry with at least 10+ years of post-graduate experience and deep knowledge in oligonucleotide chemistries and their biology.
• Previous experience with ÄKTA Oligopilot and/or MerMade oligonucleotide synthesizer platforms.
• Previous experience with oligonucleotide conjugation chemistry.
• Strong organizational and recordkeeping skills.
• Strong presentational skills to be able to communicate to both internal and external audiences.
• Strong track record of publication and presentation in oligonucleotide therapeutics field.
• Ability to work as a team player, creating a dynamic and inspirational environment.

Location(s):

Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.

Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

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This role will be a key asset in the future growth of the company. The focus of this position will be managing the budgeting, forecast and long range planning processes and serving as the business partner to all departments, especially to the R&D organization, helping department heads throughout the company in understanding and managing the performance of their respective parts of the organization. This position will partner and interact closely with the accounting team on the month end closing process.

This individual will be spear-heading the Company’s financial quarterly forecast, annual budgeting process, operating plan variance analysis, long range planning process and special projects. S/he will provide financial consulting and strategic support to senior management including preparing board presentations, financial presentations, capital expenditure analysis, industry/peer group comparisons, new business opportunities, acquisition analysis and other projects requested by senior management. The position reports to the Chief Financial Officer.

Key Responsibilities Include:

• Develop and implement best-in-class FP&A processes and procedures to drive informed decision making for executives and functional leaders with the goal to drive financial performance across the organization.
• Analyze current and past trends in key performance indicators including all expenses and capital expenditures, highlighting trends, and analyzing causes of unexpected variances.
• Manage the continued development of Budgeting, Financial Forecasting, Operating Plan and Modeling tools.
• Ad-Hoc Reporting and Analysis.
• Quarterly and Monthly Financial reports.
• Work with the Company’s business intelligence tool and dashboard reports.
• Improve performance by evaluating processes along with departmental stakeholders to drive efficiencies.
• Develop financial models and analyses to support strategic initiatives.
• Analyze complex financial information and reports to provide accurate and timely financial recommendations to management for decision making purposes.
• Supporting Senior Management Team and Departments heads with in-depth analysis.
• Prepare presentations to Board of Directors and Senior Management Team.

Required Skills & Experience:

• Bachelor’s Degree in Accounting or Finance; MBA highly preferred.
• 8+ years’ experience in Financial Planning and Analysis roles.
• Strong leadership skills required, highly driven and self-motivated.
• Experience in biotechnology preferred.
• Advanced Microsoft Excel and PowerPoint skills.
• Highest standards of accuracy and precision; highly organized.
• Articulate with excellent verbal and written communication skills.
• Financial statement knowledge and understanding of US GAAP.
• Strong team player that has a customer service approach and is solution oriented.
• Demonstrated ability to roll-up sleeves and work with team members in a hands-on management capacity.
• Experience with ERP systems including NetSuite and Adaptive Planning.

Travel:

Approximately 5% of this position may require travel.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Location(s): Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.

Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.

Apply Here

Stoke is seeking an enthusiastic, collaborative, and experienced DMPK specialist to join the Bioanalytical, DMPK and Biomarker Development group to support non-clinical and clinical DPMK activities. As a Principal Scientist/Associate Director in DMPK team, you will play a critical role in preparing and implementing strategies that will impact non-clinical and clinical development.

Key Responsibilities Include:

• Responsible for bioanalytical data and report review to ensure a high quality and timely delivery of data and study reports.
• Work with VP, DMPK in defining the technical parameters and milestones for outsourced clinical and nonclinical bioanalytical projects including method development, validation, and sample analysis.
• Provide operational support in collaboration with the clinical team, clinical sites and CROs (including, but not limited to, sample collection/processing procedures, sample shipping and handling instructions, sample reconciliation, etc.).
• Contribute to relevant module in regulatory submission documents as needed.
• Serve as the DMPK representative at research, program core team and operational team meetings.
• Identify and manage external CROs for the design and execution of in vitro/in vivo ADME, PK and bioanalytical studies.
• Provide scientific leadership and mentorship for less experienced scientists.
• Manage the successful implementation of validated bioanalytical methods at CROs in support of clinical studies.
• Participate in budgeting activities.

Required Skills & Experience:

• PhD with minimum 9 years of post-Ph.D. experience, including a minimum of 5 years industry experience in relevant field.
• Solid understanding of drug metabolism, bioanalysis, pharmacokinetics, preclinical pharmacology and clinical study designs.
• Experience in writing bioanalytical package to be included in regulatory submissions
• Industrial experience in the bioanalytical method development (LC-MS/MS, Ligand binding assays etc.) validation and sample analysis under GLP and GCP regulations.
• Strong knowledge in GLP regulations that pertain to Bioanalytical Development
• Experience in nucleic acids-based therapeutics and nonclinical toxicology is highly desired.
• Excellent communication and interpersonal skills, and proven success working in a matrix environment.

Travel:

Approximately 5% of this position may require travel.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Location(s): Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.  Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients, and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.

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The Associate Director/Director of Communications & Investor Relations will play a critical role in supporting and executing communications activities related to the company’s mission, strategic objectives, and progress. Reporting to the Vice President, Head of Corporate Affairs, this individual will play a leadership role in the company’s communications, with a particular focus on the investor relations and communications to current and prospective shareholders and sell-side analysts. S/He will be responsible for developing and executing a comprehensive investor relations strategy to support the company’s goal of ensuring an accurate understanding of the company’s vision, strategy and its fair valuation.  Serving as second in command to the VP, this person will contribute to many aspects of the Corporate Affairs function. S/He will assist with a broad scope of Corporate Affairs activities, including those related to Internal and External communications and Patient Advocacy.

Key Responsibilities Include:

• Collaborate with the VP, Head of Corporate Affairs to develop and implement an investor relations strategy and plans.
• Lead the development and implementation of the company’s Investor Relations strategy and execution, including day-to-day management of investor interactions and events (corporate calendar, non-deal roadshows, conference management, briefing materials, corporate presentations, bus tours, etc.).
• Work closely with executive leadership to establish the optimal mix of shareholders for Stoke at each stage of its evolution through strategic and thoughtful targeting initiatives.
• Work closely with cross-functional leaders and colleagues to stay current on company progress to guide investor-focused communications and then work collaboratively on materials development such as press releases, backgrounders, fact sheets, website content, Q&As, presentations, call scripts, executive talking points, social media posts, internal communications and intranet content.
• Serve as a primary point of contact for all investor inquiries; cultivate and maintain strong relationships with investors (current and potential future), sell-side research analysts, media and other key stakeholders. Provide timely, consistent, compliant and accurate responses.
• Effectively anticipate investor concerns, questions and needs by keeping current on the industry and competitive landscape while maintaining a deep understanding of Stoke’s business and progress.
• Monitor and assess market and sector dynamics as well as all investment research (including models and estimates) on Stoke and its industry peers. Provide data and metrics-driven insights into the market and competitive landscape, using the information to counsel Stoke management and guide investor communications and activities.
• Continuously evaluate Stoke’s performance with investors and use data as well as keen observation and critical thinking skills to continuously improve Stoke’s ongoing investor engagement.
• Partner closely with Finance, Legal and other departments to ensure accurate and appropriate information for financial reporting, including as part of quarterly communications and regular SEC filings.
• Serve as an internal resource for communications counsel and assist with the departmental activities including helping maintain the website, social media channels, executive visibility and patient advocacy efforts.
• Manage external agencies and vendors that are supporting investor communications and activities.

Required Experience:

• Bachelor’s Degree, preferably in Journalism, Communications, Business, Finance, Accounting or a related field. Post-graduate degree a plus.
• 7+ years of experience in the biotech or pharmaceutical industry working for/on behalf of publicly-traded, high-growth companies. Experience in investor relations, corporate communications, corporate strategy, equity research, investment banking and/or finance.
• Excellent communications skills: written, verbal and presentation delivery.
• Demonstrated ability to simplify complex information and distill it into clear, concise and simple messages that help to effectively communicate the company story.
• Results-driver with proven ability to identify and analyze business dynamics to develop and implement plans to support investor relations activities.
• Strategic thinker and problem solver; intellectually curious and perceptive; able to identify interdependencies and connections across the business; a critical thinker.
• Comfortable in a fast-moving, rapidly changing environment; able to establish structure and process when needed; consistently prioritizes high-impact projects; calm under pressure; works with a sense of purpose and urgency.
• Appreciation for laws and regulations governing the industry and publicly-traded company communications and investor engagement activities.
• Holds self and others to a high standard of ethics and integrity. Maintains confidentiality, exercises good judgment and discretion.
• Demonstrated ability to lead, influence and collaborate across the organization and at all levels, both internally and externally.
• Able to work independently with minimal supervision.

Travel:

Once investor and other meetings and conferences return to being conducted in-person, it is anticipated that approximately 25-35% of this individual’s time will be spent traveling, primarily to New York and other areas with high investor concentrations as well as other medical conferences and industry meetings.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including: medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Location(s): 

Stoke operates sites in Bedford, MA, and Cambridge, MA. The individual in this role will be an integral contributor to the team, working closely with their manager and members of the executive leadership team, and may be based primarily in one of the two locations with the ability to work from the other location as the need arises.

Since March 2020, Stoke’s office-based employees have been working from home and we have modified our business practices (including but not limited to curtailing or modifying employee travel, moving to partial remote work, and cancelling physical participation in meetings, events and conferences). We are continually assessing the impact of COVID-19 on our business and keeping in mind the best interests of our employees, patients and business partners. For the foreseeable future, we anticipate the individual in this role will work from home and participate in meetings and company events virtually. At some point, we anticipate this role will return to working at one of our physical locations.

Apply Here

Stoke is seeking a highly motivated Research Associate to join a company pioneering genetic disease treatments. A successful candidate should have a strong interest and background in cellular and molecular biology research. This candidate will be a member of the In Vitro Pharmacology Group. Tasks will focus on evaluating oligonucleotides for therapeutic projects. The candidate will support implementing and executing biochemical or cellular biological assays. The candidate will be expected to perform the following activities:

• Evaluate oligonucleotide-based drug candidates in cell-based assays.
• Conduct in vitro disease model cellular assays to evaluate drug candidates.
• Perform cell and molecular biology techniques including RNA isolation, protein isolation, RT-PCR, qPCR, western blot, and other project-specific assays, as necessary.
• Troubleshoot experiments, analyze, interpret data, participate in development of new assays.
• Maintain accurate documentation of experiments in electronic lab notebook (ELN) and draft technical reports.
• Present research findings at group meetings and occasional company-wide and external meetings.
• Work independently as well as collaborate with peers in a result-oriented research environment.

Required Experience:

• B.S/M.S. with a minimum of 5 years post-graduate experience in molecular and cell biology research, preferably in industry, or M.S. with minimum of 2 years post-graduate experience in molecular and cell biology research, preferably in industry.
• Experienced in standard cell culture techniques.
• Experience in molecular biology, RNA isolation techniques, and cell-based assays are a must.
• A plus would be prior participation in phenotypic assays, iPSC disease model assays, or antisense-based target validation.
• Work experience in therapeutic areas involving CNS or ocular disease desirable.
• Strong organizational and recordkeeping skills, experience using ELN is highly desirable.

Travel:
Approximately 5% of this position will require travel.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Location(s):

This position is based in Bedford, MA. Stoke operates sites in Bedford, MA, and Cambridge, MA.

Apply Here