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This position is primarily responsible for leading all aspects of engineering, utilities, maintenance, facilities services, construction management, facilities planning, capital project management, and EH&S functions at Stoke’s Cambridge and Bedford locations.

Duties & Responsibilities:

Specific duties and responsibilities include, but are not limited to:

• Support the design, construction, startup and operation of all locations
• Supervise external architectural, engineering and contractor relationships, with responsibility for approving related contracts and agreements
• Proactively engage with internal cross-functional teams, including Quality Assurance, Research, Clinical Development, Technical Operations, Human Resources, Finance and IT to achieve site goals and priorities
• Develop and formalize approval of documents related to site operations including SOPs, policies and procedures
• Manage projects in support of space planning and expansion across all locations to meet hiring requirements
• Develop budgets and long-range facilities plans based on company growth and future needs
• Oversee the functioning of all building systems and employment of proactive maintenance strategies
• Ensure building operations comply with all local building codes, zoning laws and regulations
• Maintain and improve site compliance related to environment, health, and safety.

Required Qualifications & Experience:

• Bachelor’s degree in engineering or related discipline preferred or equivalent combination of education and work-related experience
• Minimum of 10 years overall experience in or related to biotechnology or pharmaceutical industry required
• Must have experience in maintenance and construction projects and service vendor management
• Significant project management skills in all areas of facilities operations
• Ability to read and interpret architectural prints, job specifications etc.
• Knowledge of OSHA guidelines, and other federal, state and local regulations is required
• Excellent management skills with demonstrated organizational, administrative, interpersonal, communication and supervisory skills
• Strong focus on customer service
• Pharmaceutical GMP and GLP knowledge preferred
• Experience with asset, maintenance, and facilities management systems
• Working knowledge of EH&S

Location: Bedford

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Responsibilities:

• Research and gather information to be used in the planning, preparation, and submission of external reporting-related SEC filings.
• Ensure preparation and timely filing of Form 10-Q/10-K/8-K in accordance with U.S. GAAP and SEC requirements using ActiveDisclosure.
• Research technical accounting matters and author technical accounting memoranda regarding changes in or application of guidance and treatment of transactions.
• Actively participate in quarterly reviews and annual audits.
• Manage and actively participate in the annual budgeting process and interim forecasting process.
• Responsible for the monthly variance analysis process and reviewing results with Department Managers.
• Identify and implement budgeting software to aid in the preparation of the annual budget and forecasts.
• Collaborate to build and maintain models related to revenue, budgeting and forecasting.
• Responsible for monthly and quarterly accruals related to clinical trials and outside research agreements.
• Assist in the preparation of clinical trial budgets and tracking of expenses.
• Assist with special projects as needed.

Qualifications:

• Bachelor’s degree in either Accounting or Finance required.
• CPA or CPA candidate strongly preferred.
• Between 3-5 years of public accounting/public company experience and/or SEC reporting experience required.
• Proficient with the conceptual and practical application of U.S. GAAP.
• Working knowledge of financial reports and disclosures required.
• Working knowledge of SEC reporting requirements preferred.

Preferred Skills and Experience:

• Experience with Active Disclosure and NetSuite and/or a willingness to learn.
• Biotech/pharmaceutical industry experience preferred.
• Proficient with Microsoft Office (e.g., Outlook, Word, Excel and PowerPoint).
• Excellent written and oral communication skills.
• Strong attention to detail and accuracy.
• Strong financial modelling skills.
• Strong analytical skills.
• Self-motivated; able to work both independently to complete tasks and respond to requests and with others to utilize their resources and knowledge to identify quality solutions.
• Strong organization, planning, and project management skills; ability to prioritize tasks for self and team to meet requirements and deadlines.
• Deliver an accurate, consistent and timely work product in accordance with established deadlines and policies.

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This position will oversee all medicinal chemistry activities from Hit identification to clinical proof-of-concept. This position is responsible for creating and executing a chemistry strategy to support both discovery and early development activities, including the identification of key areas for investment, building appropriate internal and external capabilities, and communicating the company’s chemistry strategy both internally and to the external scientific community.

Duties & Responsibilities:

Specific duties and responsibilities include, but are not limited to:

• Create and execute overall chemistry plan to ensure robust, cost-effective support of company discovery and development portfolio
• Recruit high-quality chemistry personnel to support chemistry plan
• Oversee design and manufacture of oligonucleotides to support all stages of discovery and lead optimization for preclinical programs
• Evaluate and select CROs and CMOs to support key preclinical chemistry activities
• Oversee both internal chemistry team and external preclinical chemistry resources
• Oversee CMC activities for all preclinical programs
• Assist in authoring of CMC sections of regulatory submissions
• Regularly assess developments in the field of oligonucleotide therapeutics and identify areas for future investment
• Communicate chemistry strategy and activities to senior management and Board of Directors on regular basis
• Serve as primary liaison with corporate partners on all issues related to medicinal chemistry
• Present updates of Stoke platform and chemistry developments at key scientific conferences
• Willingness to live and work in Boston area
• Occasional travel for oversight of external CROs is expected

Required Qualifications & Experience:

• A Ph.D. in organic chemistry or medicinal chemistry or related discipline
• At least 15 years of industry experience, including at least 10 years in oligonucleotide therapeutics
• Demonstrated success in the design, medicinal chemical optimization, and formulation/delivery of oligonucleotide therapeutics
• Previous experience in the GMP manufacture of oligonucleotide therapeutics, either directly or through a contract manufacturer, is a plus
• Previous experience authoring CMC sections of regulatory submissions is a plus
• Proven experience managing multiple direct reports
• Strong presentation skills to facilitate communication with both internal and external audiences
• Strong decision-making skills to facilitate execution of timelines
• Ability to work as a team player

Location: Bedford & Cambridge

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