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Muthiah (Mano) Manoharan is a world-leading chemist in the areas of oligonucleotide chemical modifications, conjugation chemistry, and delivery platforms. Dr. Manoharan is currently Senior Vice President of Innovation Chemistry, a Scientific Advisory Board Member, and a Distinguished Research Scientist at Alnylam Pharmaceuticals. He and his team pioneered the discovery and development of the chemical modifications that make RNA interference-(RNAi) based human therapeutics possible. He has authored more than 215 publications and over 400 abstracts and is the inventor of more than 250 issued U.S. patents. Prior to Alnylam, Dr. Manoharan worked at Ionis (formerly Isis) Pharmaceuticals in the field of antisense oligonucleotide therapeutics. Dr. Manoharan has been honored with the 2019 Lifetime Achievement Award of the Oligonucleotide Therapeutics Society.